Organic Chemistry Portal



Direct Cross-Coupling Access to Diverse Aromatic Sulfide: Palladium-Catalyzed Double C-S Bond Construction Using Na2S2O3 as a Sulfurating Reagent

Zongjun Qiao, Jianpeng Wei and Xuefeng Jiang*

*Shanghai Key Laboratory of Green Chemistry and Chemical Process, Department of Chemistry, East China Normal University, 3663 North Zhonshan Road, Shanghai 200062, P. R. China, Email:

Z. Qiao, J. Wei, X. Jiang, Org. Lett., 2014, 16, 1212-1215.

DOI: 10.1021/ol500112y

see article for more reactions


The odorless and stable solid Na2S2O35H2O was used as a convenient and environmentally friendly source of sulfur in a Pd-catalyzed cross-coupling of aryl halides and alkyl halides to deliver aromatic sulfides.

see article for more examples

Key Words

aryl sulfides, multicomponent reactions

ID: J54-Y2014