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Vicinal Difunctionalization of Alkenes: Chlorotrifluoromethylation with CF3SO2Cl by Photoredox Catalysis

Se Hwan Oh, Yashwardhan R. Malpani, Neul Ha, Young-Sik Jung* and Soo Bong Han*

*Division of Drug Discovery Research, Korea Research Institute of Chemical Technology, P.O. Box 107, Yuseong, Daejeon 305-600, Republic of Korea, Email:,

S. H. Oh, Y. R. Malpani, N. Ha, Y.-S. Jung, S. B. Han, Org. Lett., 2014, 16, 1310-1313.

DOI: 10.1021/ol403716t (free Supporting Information)

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In a photoredox vicinal chlorotrifluoromethylation in the presence of Ru(Phen)3Cl2 as catalyst, various terminal and internal alkenes can be transformed to their vicinal chlorotrifluoromethylated derivatives using CF3SO2Cl as a source for CF3 radicals and chloride ions.

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Key Words

trifluoromethylation, chlorination

ID: J54-Y2014