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Catalytic C-H α-Trifluoromethylation of α,β-Unsaturated Carbonyl Compounds

Zhongxue Fang, Yongquan Ning, Pengbing Mi, Peiqiu Liao and Xihe Bi*

*Department of Chemistry, Northeast Normal University, Changchun 130024, China, Email: bixh507nenu.edu.cn

Z. Fang, Y. Ning, P. Mi, P. Liao, X. Bi, Org. Lett., 2014, 16, 1522-1525.

DOI: 10.1021/ol5004498 (free Supporting Information)



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Abstract

A copper(I)-catalyzed, regioselective C-H α-trifluoromethylation of α,β-unsaturated carbonyl compounds as well as α,β-unsaturated esters, thioesters, and amides using Togni's reagent afforded the corresponding (E)-α-trifluoromethylated products in good yields.

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Key Words

Trifluormethylation


ID: J54-Y2014