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Practical Synthesis of Phthalimides and Benzamides by a Multicomponent Reaction Involving Arynes, Isocyanides, and CO2/H2O

Trinadh Kaicharla, Manikandan Thangaraj and Akkattu T. Biju*

*Organic Chemistry Division, CSIR-National Chemical Laboratory (CSIR-NCL), Dr. Homi Bhabha Road, Pune - 411008, India, Email:

T. Kaicharla, M. Thangaraj, A. T. Biju, Org. Lett., 2014, 16, 1728-1731.

DOI: 10.1021/ol500403x

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Transition-metal-free multicomponent reactions involving arynes, isocyanides, and CO2 as the third component resulted in the formation of N-substituted phthalimides in good yields, whereas the use of water as the third component furnished benzamide derivatives in good yields. These reactions took place under mild conditions with broad scope.

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Key Words

Phthalimides, Protecting Groups

ID: J54-Y2014