An Efficient Synthesis of 2-Substituted Quinazolin-4(3H)-ones Catalyzed by Iron(III) Chloride
Ramamohan Mekala, Raghunadh Akula, Raghavendra Rao Kamaraju, Chandrasekhar Kothapalli Bannoth, Sridhar Regati, Jayaprakash Sarva*
*Technology Development Centre, Custom Pharmaceutical
Services, Dr. Reddy's Laboratories Ltd, Bollaram Road, Miyapur, Hyderabad,
500049, India, Email: sarvaj
drreddys.com
R. Mekala, R. Akula, R. R. Karmaju, C. K. Bannoth, S. Regati, J. Sarva, Synlett, 2014, 25, 821-826.
DOI: 10.1055/s-0033-1340786
Abstract
The iron(III) chloride catalyzed reaction of isatoic anhydride with various amidoxime derivatives enables a simple and highly efficient synthesis of 2-substituted quinazolin-4(3H)-ones. The conversion of several aryl and alkyl amidoximes demonstrates the scope of the methodology.
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Key Words
heterocycles, polycycles, ketones, catalysis, iron, quinazolinones
ID: J60-Y2014
