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Conversion of Pyridine N-Oxides to Tetrazolopyridines

Shanshan Liu, Dieter Lentz and C. Christoph Tzschucke*

*Freie Universität Berlin, Institut für Chemie und Biochemie, Takustrasse 3, 14195 Berlin, Germany, Email:

S. Liu, D. Lentz, C. C. Tzschucke, J. Org. Chem., 2014, 79, 3249-3254.

DOI: 10.1021/jo500231m (free Supporting Information)


Treatment of pyridine N-oxides with 4-toluene sulfonyl chloride and sodium azide in toluene at elevated temperature enables an efficient and convenient synthesis of tetrazolopyridines.

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proposed mechanism

Key Words


ID: J42-Y2014