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Co-Catalyzed Synthesis of 1,4-Dicarbonyl Compounds Using TBHP Oxidant

Feng Zhang, Peng Du, Jijun Chen, Hongxiang Wang, Qiang Luo and Xiaobing Wan*

*Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China, Email: wanxbsuda.edu.cn

F. Zhang, P. Du, J. Chen, H. Wang, Q. Luo, X. Wan, Org. Lett., 2014, 16, 1932-1935.

DOI: 10.1021/ol5004687 (free Supporting Information)


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Abstract

In a Co-catalyzed reaction for the construction of 1,4-dicarbonyls, a cascade organocobalt addition/trapping/Kornblum-DeLaMare rearrangement were involved. The reaction offers easy availability of starting materials, wide substrate scope, high functionality tolerance, and operational simplicity.

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Key Words

1,4-keto carboxylic derivatives, 1,4-dicarbonyl compounds, oxidation of alkenes, TBHP


ID: J54-Y2014