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Direct C-H Bond Arylation of (Benzo)oxazoles with Aryl Chlorides Catalyzed by N-Heterocyclic Carbene-Palladium(II)-1-Methylimidazole Complex

Xiao-Bao Shen, Yun Zhang, Wen-Xin Chen, Zheng-Kang Xiao, Ting-Ting Hu and Li-Xiong Shao*

*College of Chemistry and Materials Engineering, Wenzhou University, Chashan University Town, Wenzhou, Zhejiang Province 325035, People’s Republic of China, Email: Shaolixwzu.edu.cn

X.-B. Shen, Y. Zhang, W.-X. Chen, Z.-K. Xiao, T.-T. Hu, L. X. Shao, Org. Lett., 2014, 16, 1984-1987.

DOI: 10.1021/ol500531m (free Supporting Information)



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Abstract

The direct C-H bond arylation of benzoxazoles and oxazoles with aryl chlorides is catalyzed by a well-defined NHC-Pd(II)-Im complex. Under optimized conditions, various aryl chlorides can be used to yield 2-aryloxazole derivatives in good yields.

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Key Words

benzoxazoles


ID: J54-Y2014