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Lanthanum(III) Triflate Catalyzed Direct Amidation of Esters

Hiroyuki Morimoto*, Risa Fujiwara, Yuhei Shimizu, Kazuhiro Morisaki and Takashi Ohshima*

*Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, 812-8582, Japan, Email:,

H. Morimoto, R. Fujiwara, Y. Shimizu, K. Morisaki, T. Ohshima, Org. Lett., 2014, 16, 2018-2021.

DOI: 10.1021/ol500593v (free Supporting Information)


Lanthanum trifluoromethanesulfonate is an effective catalyst for the coupling of esters with amides to yield amides under mild conditions.

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ID: J54-Y2014