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Staudinger Condensation for the Preparation of Thiohydantoins

Sandrine Gosling, Chahrazade El Amri, Arnaud Tatibouët*

*Institut de Chimie Organique et Analytique UMR 7311 - CNRS, Université d'Orléans, BP 6759, 45067 Orléans Cedex 2, France, Email:

S. Gosling, C. El Amri, A. Tatibouët, Synthesis, 2014, 46, 1079-1084.

DOI: 10.1055/s-0033-1338592

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Formation of iminophosphoranes in a Staudinger reaction and condensation with carbon disulfide followed by condensation with α-amino esters provides N-3-substituted 2-thiohydantoins.

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Key Words

N-heterocycles, aza-Wittig reaction, Staudinger reaction, amino acids, thiohydantoins, hydantoins

ID: J66-Y2014