Metal-Free Iodination of Arylboronic Acids and the Synthesis of Biaryl Derivatives
Liting Niu, Hao Zhang, Haijun Yang, Hua Fu*
*Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China, Email: fuhua
mail.tsinghua.edu.cn
L. Niu, H. Zhang, H. Yang, H. Fu, Synlett, 2014, 25, 995-1000.
DOI: 10.1055/s-0033-1340871
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Abstract
A simple, general and efficient method enables a metal-free iodination of arylboronic acids with molecular iodine as the halide source and potassium carbonate as the base. The method tolerates various functional groups and can also be applied very effectively in a one-pot, two-step synthesis of biaryl derivatives.
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Key Words
arylboronic acids, iodination, cross-coupling, Suzuki coupling, biaryl derivatives
ID: J60-Y2014
