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Chemoselective Palladium-Catalyzed Cyanation of Alkenyl Halides

Kimberley J. Powell, Li-Chen Han, Pallavi Sharma and John E. Moses*

*School of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD, U.K., Email:

K. J. Powell, L-C. Han, P. Sharma, J. E. Moses, Org. Lett., 2014, 16, 2158-2161.

DOI: 10.1021/ol500618w

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A palladium-catalyzed cyanation of alkenyl halides using acetone cyanohydrin enables the preparation of structurally diverse alkenylic nitrile containing compounds in one step. The reaction is efficient, chemoselective, easy to perform, and tolerates a number of functional groups.

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Key Words

akenyl nitriles

ID: J54-Y2014