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Cs2CO3-Promoted One-Pot Synthesis of Alkynylphosphonates, -phosphinates, and -phosphine Oxides

Yulei Wang, Jiepeng Gan, Liu Liu, Hang Yuan, Yuxing Gao*, Yan Liu* and Yufen Zhao

*Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian 361005, China, Email:,

Y. Wang, J. Gan, L. Liu, H. Yuan, Y. Gao, Y. Liu, Y. Zhao, J. Org. Chem., 2014, 79, 3678-3683.

DOI: 10.1021/jo500312n (free Supporting Information)

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Efficient Cs2CO3-promoted phosphorylations or phosphinylations of various 1,1-dibromo-1-alkenes with readily available trialkyl phosphites, ethyl diphenylphosphinite, or diethyl phenylphosphonite under metal-free conditions provide valuable alkynylphosphonates, -phosphinates, and -phosphine oxides in very good yields.

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Key Words

phosphonates, phosphinates, phosphine oxides

ID: J42-Y2014