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Pd-Catalyzed Oxidative Annulation of Hydrazides with Isocyanides: Synthesis of 2-Amino-1,3,4-oxadiazoles

Tao Fang, Qitao Tan, Zhengwei Ding, Bingxin Liu and Bin Xu*

*Department of Chemistry, Innovative Drug Research Center, Shanghai University, Shanghai 200444, China, Email:

T. Fang, Q. Tan, Z. Ding, B. Liu, B. Xu, Org. Lett., 2014, 16, 2342-2345.

DOI: 10.1021/ol5006449

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Efficient palladium-catalyzed sequential isocyanide insertions into N-H and O-H bonds of hydrazides followed by oxidative annulation provide a convenient access to valuable 2-amino-1,3,4-oxadiazoles and their derivatives.

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Key Words

1,3,4-oxadiazoles, oxygen

ID: J54-Y2014