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Efficient and Fast Method for the Preparation of Diaryl Ketones at Room Temperature

Abdol Reza Hajipour*, Raheleh Pourkaveh

*Pharmaceutical Research Laboratory, College of Chemistry, Isfahan University of Technology, Isfahan 84156, Iran, Email: hajicc.iut.ac.ir

A. R. Hajipour, R. Pourkaveh, Synlett, 2014, 25, 1101-1105.

DOI: 10.1055/s-0033-1341070 (free Supporting Information)


Abstract

Palladium-catalyzed cross-coupling of aryl boronic acids with acyl chlorides at room temperature under phosphine-free conditions affords the corresponding aryl ketones in excellent yields within short times. This synthetic method overcomes common disadvantages of Friedel-Crafts acylation procedures and is compatible with a broad range of acyl chlorides.

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Key Words

palladium, aromatic ketones, acid chlorides, arylboronic acids, room temperature


ID: J60-Y2014