Ligand-Free Copper(I) Oxide Nanoparticle Catalyzed Three-ComponentSynthesis of 2H-Indazole Derivatives from 2-Halobenzaldehydes, Amines and Sodium Azide in Polyethylene Glycol as a Green Solvent
Hashem Sharghi*, Mahdi Aberi
*Department of Chemistry, Shiraz University, Shiraz, 71454, Iran, Email: shashemchem.susc.ac.ir
H. Sharghi, M. Aberi, Synlett, 2014, 25, 1111-1115.
DOI: 10.1055/s-0033-1340979 (free Supporting Information)
An efficient synthesis of 2H-indazole derivatives in a one-pot three-component reaction of 2-chloro- and 2-bromobenzaldehydes, primary amines and sodium azide is catalyzed by copper(I) oxide nanoparticles (Cu2O-NP) under ligand-free conditions in polyethylene glycol (PEG 300) as a green solvent.
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