Ligand-Free Copper(I) Oxide Nanoparticle Catalyzed Three-Component­Synthesis of 2H-Indazole Derivatives from 2-Halobenzaldehydes, Amines and Sodium Azide in Polyethylene Glycol as a Green Solvent

Hashem Sharghi*, Mahdi Aberi

*Department of Chemistry, Shiraz University, Shiraz, 71454, Iran, Email: shashemchem.susc.ac.ir

H. Sharghi, M. Aberi, Synlett, 2014, 25, 1111-1115.

DOI: 10.1055/s-0033-1340979

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Abstract

An efficient synthesis of 2H-indazole derivatives in a one-pot three-component reaction of 2-chloro- and 2-bromobenzaldehydes, primary amines and sodium azide is catalyzed by copper(I) oxide nanoparticles (Cu₂O-NP) under ligand-free conditions in polyethylene glycol (PEG 300) as a green solvent.

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Key Words

Cu₂O nanoparticles, 2H-indazoles, ligand-free, multicomponent reactions, green chemistry

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ID: J60-Y2014