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CuBr-Promoted Formal Hydroacylation of 1-Alkynes with Glyoxal Derivatives: An Unexpected Synthesis of 1,2-Dicarbonyl-3-enes

Shufeng Chen*, Xiaojie Li, Haiying Zhao and Baoguo Li

*Department of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot 010021, People's Republic of China, Email: shufengchenimu.edu.cn

S. Chen, Y. Li, H. Zhao, B. Li, J. Org. Chem., 2014, 79, 4137-4141.

DOI: 10.1021/jo500199v (free Supporting Information)


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Abstract

A copper-promoted reaction of 1-alkynes with α-carbonyl aldehydes in the presence of morpholine enables an efficient and highly regio- and stereoselective synthesis of E-1,2-dicarbonyl-3-ene derivatives.

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Key Words

enones, unsaturated compounds


ID: J42-Y2014