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Amberlyst A26 OH as a Recyclable Catalyst for Hydration of Nitriles and Water-Based Synthesis of 4(1H)-Quinazolinones from 2-Aminobenzonitrile and Carbonyl Compounds

Fatemeh Tamaddon*, Farzaneh Pouramini

*Department of Chemistry, Faculty of Science, Yazd University, Yazd 89195-741, Iran, Email:

F. Tamaddon, F. Pouramini, Synlett, 2014, 25, 1127-1131.

DOI: 10.1055/s-0033-1340986


Macroporous Amberlyst A26 OH catalyzes a selective hydration of nitriles to primary amides as well as a base-catalyzed synthesis of 2-substituted 4(1H)-quinazolinones via reaction of 2-aminobenzonitrile with carbonyl compounds in H2O-EtOH.

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Key Words

hydration, nitriles, amides, 2,3-dihydroquinazolinones, Amberlyst A26 OH, recyclable catalyst

ID: J60-Y2014