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A Highly Active and Air-Stable Ruthenium Complex for the Ambient Temperature Anti-Markovnikov Reductive Hydration of Terminal Alkynes

Mingshuo Zeng, Le Li and Seth B. Herzon*

*Department of Chemistry, Yale University, New Haven, Connecticut 06520, United States, Email:

M. Zeng, L. Li, S. B. Herzon, J. Am. Chem. Soc., 2014, 136, 7058-7067.

DOI: 10.1021/ja501738a


An air-stable half-sandwich ruthenium complex is a highly active catalyst for the anti-Markovnikov reductive hydration of alkynes, involving the decarboxylation of formic acid, hydration of the alkyne, and hydrogenation of the intermediate aldehyde. A wide array of terminal alkynes are efficiently processed to linear alcohols using as little as 2 mol % of catalyst at ambient temperature.

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Key Words

saturated alcohols, formic acid

ID: J48-Y2014