2,2,2-Trifluoroacetophenone: An Organocatalyst for an Environmentally Friendly Epoxidation of Alkenes

Dimitris Limnios and Christoforos G. Kokotos*

*Laboratory of Organic Chemistry, Department of Chemistry, University of Athens, Panepistimiopolis, 15771 Athens, Greece, Email: ckokotoschem.uoa.gr

D. Limniois, C. G. Kokotos, J. Org. Chem., 2014, 79, 4270-4276.

DOI: 10.1021/jo5003938

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Abstract

2,2,2-trifluoroacetophenone is an efficient organocatalyst for a cheap, mild, fast, and environmentally friendly epoxidation of alkenes. Various olefins, mono-, di-, and trisubstituted, are epoxidized chemoselectively in high to quantitative yields utilizing low catalyst loadings and H₂O₂ as a green oxidant.

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Key Words

epoxidation, organocatalysis

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ID: J42-Y2014