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A Highly Efficient Cu-Catalyzed S-Transfer Reaction: From Amine to Sulfide

Yiming Li, Jiahua Pu and Xuefeng Jiang*

*Shanghai Key Laboratory of Green Chemistry and Chemical Process, Department of Chemistry, East China Normal University, Shanghai 200062, P. R. China, Email: xfjiangchem.ecnu.edu.cn

Y. Li, J. Pu, X. Jiang, Org. Lett., 2014, 16, 2692-2695.

DOI: 10.1021/ol5009747


Abstract

Inodorous stable Na2S2O3 is used as a sulfurating reagent in a Cu-catalyzed dual C-S bonds formation reaction, that proceeds in alcohol and water under air. This powerful strategy provides a practical and efficient approach to construct thioethers, using readily available aromatic amines and alkyl halides as starting materials. Sensitive and synthetic useful functional groups are tolerated.


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Key Words

aryl sulfides, Sandmeyer Reaction


ID: J54-Y2014