Nickel-Catalyzed Cross-Coupling of Aryl Fluorides and Organozinc Reagents
Feng Zhu and Zhong-Xia Wang*
*CAS Key Laboratory of Soft Matter Chemistry and Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, People’s Republic of China, Email: zxwangustc.edu.cn
F. Zhu, Z.-X. Wang, J. Org. Chem., 2014, 79, 4285-4292.
DOI: 10.1021/jo500619f (free Supporting Information)
Ni(PCy3)2Cl2 effectively catalyzes cross-coupling of aryl fluorides and organozinc reagents. Both electron-poor and -rich aryl fluorides can react effectively with nucleophiles including aryl-, methyl-, and benzylzinc chlorides. A wide range of substituents and functional groups are tolerated.
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