One-Pot Synthesis of Ureas from Boc-Protected Amines
Constantinos Spyropoulos and Christoforos G. Kokotos*
*Laboratory of Organic Chemistry, Department of Chemistry, University of Athens, Panepistimiopolis 15771, Athens, Greece, Email: ckokotoschem.uoa.gr
C. Spyropoulos, C. G. Kokotos, J. Org. Chem., 2014, 79, 4477-4483.
DOI: 10.1021/jo500492x (free Supporting Information)
In a practical one-pot synthesis of ureas, Boc-protected amines are transformed into nonsymmetrical and symmetrical disubstituted and trisubstituted ureas via in situ generation of isocyanates utilizing 2-chloropyridine and trifluoromethanesulfonyl anhydride. A variety of amines can be employed successfully, leading to high yields of isolated ureas.
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