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Copper-Catalyzed Regio- and Stereoselective Intermolecular Three-Component Oxyarylation of Allenes

Taisuke Itoh, Yohei Shimizu* and Motomu Kanai*

*Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan, Email:,

T. Itoh, Y. Shimizu, M. Kanai, Org. Lett., 2014, 16, 2736-2739.

DOI: 10.1021/ol501022d

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A copper(II)-catalyzed intermolecular three-component oxyarylation of allenes using arylboronic acids as a carbon source and TEMPO as an oxygen source proceeded under mild conditions with high regio- and stereoselectivity and functional group tolerance.

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Key Words

alkenylation, allylic alcohols, MnO2, TEMPO, multicomponent reactions

ID: J54-Y2014