Transamidation of Carboxamides Catalyzed by Fe(III) and Water
Liliana Becerra-Figueroa , Andrea Ojeda-Porras and Diego Gamba-Sánchez*
*Laboratory of Organic Synthesis, Bio and Organocatalysis,
Chemistry Department, Universidad de los Andes, Cra 1 No. 18A-12 Q:305, Bogotá
111711, Colombia, Email: da.gamba1361
uniandes.edu.co
L. Becerra-Figueroa , A. Ojeda-Porras, D. Gamba-Sánchez, J. Org. Chem., 2014, 79, 4544-4552.
DOI: 10.1021/jo500562w
see article for more reactions
Abstract
A highly efficient transamidation of several primary, secondary, and tertiary amides with aliphatic and aromatic amines (primary and secondary) is performed in the presence of a 5 mol % concentration of different hydrated salts of Fe(III). The methodology was also applied to urea and phthalimide to demonstrate its versatility and wide substrate scope. A plausible mechanism explains the crucial role of water.
see article for more examples
While ads financed 62% of the published abstracts in 2024, donations allowed us to publish additional 12%. 26% of the abstracts have been published voluntarly. If you kindly donate, we can publish more freely accessible information and help the chemical community even more:
If you don't like pawalls or a flood of more and more advertising, then you can send a clear signal here!
Key Words
ID: J42-Y2014
