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A Mild and Base-Free Synthesis of Unsymmetrical Diaryl Sulfones from Arylboronic Acids and Arylsulfonyl Hydrazides

Xiang-mei Wu*, Yan Wang

*Department of Chemistry, College of Science, Lishui University, Lishui, Zhejiang 323000, P. R. of China, Email:

X.-m. Wu, Y. Wang, Synlett, 2014, 25, 1163-1167.

DOI: 10.1055/s-0033-1341023

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A mild and efficient synthesis of diaryl sulfones from arylboronic acids and arylsulfonyl hydrazides is described. Promoted by cupric acetate and in the absence of additional ligand and base, the cross-coupling reaction could afford a series of unsymmetrical diaryl sulfones in moderate to good yields at room temperature under neutral and ambient conditions.

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Key Words

diaryl sulfones, arylboronic acids, arylsulfonyl hydrazides, cross-coupling reaction, copper

ID: J60-Y2014