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Enantiospecific Intramolecular Heck Reactions of Secondary Benzylic Ethers

Michael R. Harris, Mikhail O. Konev and Elizabeth R. Jarvo*

*Department of Chemistry, University of California, Irvine, California 92697-2025, United States, Email:

M. R. Harris, M. O. Konev, E. R. Jarvo, J. Am. Chem. Soc., 2014, 136, 7825-7828.

DOI: 10.1021/ja5026485

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Stereospecific, nickel-catalyzed Heck cyclizations of secondary benzylic ethers proceeds in high yield and enantiospecificity to yield enantioenriched methylenecyclopentanes for benzylic ethers of both π-extended and simple arenes.

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Key Words

cyclopentanes, Heck reaction

ID: J48-Y2014