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Regioselective Hydrothiolation of Alkenes Bearing Heteroatoms with Thiols Catalyzed by Palladium Diacetate

Taichi Tamai and Akiya Ogawa*

*Department of Applied Chemistry, Graduate School of Engineering, Osaka Prefecture University, 1-1 Gakuen-cho, Nakaku, Sakai, Osaka 599-8531, Japan, Email: ogawachem.osakafu-u.ac.jp

T. Tamai, A. Ogawa, J. Org. Chem., 2014, 79, 5028-5035.

DOI: 10.1021/jo500586a (free Supporting Information)


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Abstract

A Pd-catalyzed addition of thiols to alkenes bearing a heteroatom, such as oxygen and nitrogen, proceeds under mild conditions to give regioselectively the corresponding Markovnikov adducts in good yields.

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Key Words

oxathioacetals


ID: J42-Y2014