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I2-Catalyzed Oxidative Cross-Coupling of Methyl Ketones and Benzamidines Hydrochloride: A Facile Access to α-Ketoimides

Xia Wu, Qinghe Gao, Shan Liu and Anxin Wu*

*Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, P. R. China, Email:

X. Wu, Q. Gao, S. Liu, A. Wu, Org. Lett., 2014, 16, 2888-2891.

DOI: 10.1021/ol501029w


An iodine-catalyzed oxidative C-H/N-H cross-coupling enables an efficient construction of α-ketoimides in good to excellent yields from methyl ketones and benzamidines hydrochloride under metal-free and peroxide-free conditions.

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Key Words

imides (coupling, oxidation), I2, DMSO

ID: J54-Y2014