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Palladium-Catalyzed One-Pot Synthesis of Quinazolinones via tert-Butyl Isocyanide Insertion

Xiao Jiang, Ting Tang, Jin-Mei Wang, Zhong Chen, Yong-Ming Zhu* and Shun-Jun Ji*

*College of Pharmaceutical Sciences and College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123, China, Email: zhuyongmingsuda.edu.cn, shunjunsuda.edu.cn

X. Jiang, T. Tang, J.-M. Wang, Z. Chen, Y.-M. Zhu, S.-J. Ji, J. Org. Chem., 2014, 79, 5082-5087.

DOI: 10.1021/jo500636y


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Abstract

An operational simple palladium-catalyzed three-component reaction of readily available 2-aminobenzamides, aryl halides, and tert-butyl isocyanide efficiently constructs quinazolin-4(3H)-ones in good yields via a palladium-catalyzed isocyanide insertion/cyclization sequence.

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Key Words

Quinazolinones, Multicomponent Reactions


ID: J42-Y2014