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Efficient Access to 2,3-Diarylimidazo[1,2-a]pyridines via a One-Pot, Ligand-Free, Palladium-Catalyzed Three-Component Reaction under Microwave Irradiation

Yuanxiang Wang, Brendan Frett and Hong-yu Li*

*The University of Arizona Cancer Center, Tucson, Arizona 85724, United States, Email: hongyulipharmacy.arizona.com

Y. Wang, B. Frett, H.-y. Li, Org. Lett., 2014, 16, 3016-3019.

DOI: 10.1021/ol501136e (free Supporting Information)


Abstract

Microwave irradiation enables an expeditious one-pot, ligand-free, Pd(OAc)2-catalyzed, three-component reaction for the synthesis of 2,3-diarylimidazo[1,2-a]pyridines. This methodology offers high availability of commercial reagents and great efficiency in expanding molecule diversity.

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Key Words

imidazo[1,2-a]pyridines, multicomponent reactions, microwave synthesis


ID: J54-Y2014