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Selective Reduction of Halogenated Nitroarenes with Hydrazine Hydrate in the Presence of Pd/C

Fang Li, Brendan Frett, Hong-yu Li*

*College of Pharmacy, Department of Pharmacology and Toxicology, The University of Arizona, Tucson, AZ 85721, USA, Email:

F. Li, B. Frett, H.-y Li, Synlett, 2014, 25, 1403-1408.

DOI: 10.1055/s-0033-1339025 (free Supporting Information)

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Several bromo, chloro, iodo and multihalogenated nitroarenes have been selectively reduced with hydrazine hydrate in the presence of Pd/C to give the corresponding halogenated anilines in good yield. Using microwave irradiation at elevated temperature and pressure, dehalogenated products can be isolated.

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Key Words

reduction of nitro compounds, hydrazine hydrate, palladium on carbon, aromatic amines, transfer hydrogenation

ID: J60-Y2014