N-Heterocyclic Carbene-Palladium(II)-1-Methylimidazole Complex-Catalyzed Direct C-H Bond Arylation of (Benz)imidazoles with Aryl Chlorides
Zheng-Song Gu, Wen-Xin Chen and Li-Xiong Shao*
*College of Chemistry and Materials Engineering, Wenzhou University, Chashan University Town, Wenzhou, Zhejiang Province 325035, People’s Republic of China, Email: shaolixwzu.edu.cn
Z.-S. Gu, W.-X. Chen, L-X. Shao, J. Org. Chem., 2014, 79, 5806-5811.
DOI: 10.1021/jo5010058 (free Supporting Information)
see article for more reactions
A well-defined NHC-Pd(II)-Im complex enables a facile and alternative methodology for the direct C-H bond arylation of (benz)imidazoles with (hetero)aryl chlorides. Various activated, unactivated, and deactivated (hetero)aryl chlorides were used as arylating reagents to yield 2-(hetero)aryl (benz)imidazoles in good yields.
see article for more examples