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Room-Temperature Ligand-Free Pd/C-Catalyzed C-S Bond Formation: Synthesis of 2-Substituted Benzothiazoles

Yannan Cheng, Qian Peng, Weigang Fan and Pixu Li*

*Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering, and Materials Science, Soochow University, 199 RenAi Road, Suzhou, Jiangsu 215123, China, Email:

Y. Cheng, Q. Peng, W. Fan, P. Li, J. Org. Chem., 2014, 79, 5812-5819.

DOI: 10.1021/jo5002752


The use of Pd/C as catalyst enables a ligand-free and additive-free synthesis of 2-substituted benzothiazoles via cyclization of o-iodothiobenzanilide derivatives at room temperature. The protocol is high-yielding and involves very mild conditions.

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ID: J42-Y2014