Hypervalent Iodine-Promoted α-Fluorination of Acetophenone Derivatives with a Triethylamine·HF Complex
Tsugio Kitamura*, Kensuke Muta and Kazutaka Muta
*Department of Chemistry and Applied Chemistry, Graduate
School of Science and Engineering, Saga University, Honjo-machi, Saga 840-8502,
Japan, Email: kitamura
cc.saga-u.ac.jp
T. Kitamura, K. Muta, K. Muta, J. Org. Chem., 2014, 79, 5842-5846.
DOI: 10.1021/jo500691b
Abstract
The direct fluorination reaction of acetophenone derivatives, acetonaphthones, benzyl phenyl ketone, propiophenone, butyrophenone, 1-indanone, and phenacyl chloride using iodosylarenes and TEA·5HF gives the corresponding α-fluoroketone derivatives in good yields under mild conditions except for use of a HF reagent.
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Key Words
fluorination, iodosylbenzene, hypervalent iodine reagents
ID: J42-Y2014
