ZnO-Supported Pd Nanoparticle-Catalyzed Ligand- and Additive-Free Cyanation of Unactivated Aryl Halides Using K4[Fe(CN)6]
Tanmay Chatterjee, Raju Dey and Brindaban C. Ranu*
*Department of Organic Chemistry, Indian Association for the Cultivation of Science, Jadavpur, Kolkata-700032, India, Email: ocbcriacs.res.in
T. Chatterjee, R. Dey, B. C. Ranu, J. Org. Chem., 2014, 79, 5875-5875.
DOI: 10.1021/jo500820q (free Supporting Information)
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A ZnO-supported palladium(0) nanoparticle catalyst has been applied for the efficient cyanation of a variety of functionalized aryl bromides and activated aryl chlorides with K4[Fe(CN)6] as benign cyanide source. This process circumvents the need for an additive and a ligand and offers high product yields, low catalyst loading (0.2 mol-% Pd), and recyclability of the catalyst.
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