Copper-Catalyzed N-tert-Butylation of Aromatic Amines under Mild Conditions Using tert-Butyl 2,2,2-Trichloroacetimidate
John W. Cran*, Dinesh V. Vidhani, Marie E. Krafft
*Department of Chemistry and Biochemistry, Florida State University, Tallahassee, FL 32306-4390, USA, Email: jcranchem.fsu.edu
J. W. Cran, D. V. Vidhani, M. E. Krafft, Synlett, 2014, 25, 1550-1554.
DOI: 10.1055/s-0033-1339107
Abstract
Various aromatic amines expediently underwent a copper-catalyzed N-tert-butylation in the presence of tert-butyl 2,2,2-trichloroacetimidate at room temperature.
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Key Words
anilines, tert-butylation, copper, catalysis, alkylation
ID: J60-Y2014