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Copper-Catalyzed N-tert-Butylation of Aromatic Amines under Mild Condi­tions Using tert-Butyl 2,2,2-Trichloroacetimidate

John W. Cran*, Dinesh V. Vidhani, Marie E. Krafft

*Department of Chemistry and Biochemistry, Florida State University, Tallahassee, FL 32306-4390, USA, Email: jcranchem.fsu.edu

J. W. Cran, D. V. Vidhani, M. E. Krafft, Synlett, 2014, 25, 1550-1554.

DOI: 10.1055/s-0033-1339107 (free Supporting Information)


Abstract

Various aromatic amines expediently underwent a copper-catalyzed N-tert-butylation in the presence of tert-butyl 2,2,2-trichloroacetimidate at room temperature.

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Key Words

anilines, tert-butylation, copper, catalysis, alkylation


ID: J60-Y2014