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Diarylrhodates as Promising Active Catalysts for the Arylation of Vinyl Ethers with Grignard Reagents

Takanori Iwasaki, Yoshinori Miyata, Ryo Akimoto, Yuuki Fujii, Hitoshi Kuniyasu and Nobuaki Kambe*

*Department of Applied Chemistry, Graduate School of Engineering, Osaka University, Suita, Osaka 565-0871, Japan, Email:

T. Iwasaki, Y. Miyata, R. Akimoto, Y. Fujii, H. Kuniyasu, N. Kambe, J. Am. Chem. Soc., 2014, 136, 9260-9263.

DOI: 10.1021/ja5043534 (free Supporting Information)


Cross-coupling reactions of vinyl ethers with aryl Grignard reagents are efficiently catalyzed by anionic diarylrhodium complexes, generated in situ from [RhCl(cod)]2 and the aryl Grignard reagents. In this catalytic system, vinyl-O bonds were preferably cleaved over Ar-O or Ar-Br bonds.

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ID: J48-Y2014