Palladium-Catalyzed Formylation of Aryl Halides with tert-Butyl Isocyanide

Xiao Jiang, Jin-Mei Wang, Ying Zhang, Zhong Chen, Yong-Ming Zhu* and Shun-Jun Ji*

*State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. Chinan, Email: zhuyongmingsuda.edu.cn, shunjunsuda.edu.cn

X. Jiang, J.-M. Wang, Y. Zhang, Z. Chen, Y.-M. Zhu, S.-J. Ji, Org. Lett., 2014, 16, 3492-3495.

DOI: 10.1021/ol5014262

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Abstract

A palladium-catalyzed formylation of aryl halides with isocyanide in the presence of Et₃SiH provides important aldehydes in good yield. This reaction offers mild conditions, convenient operation, low toxicity, and wide functional group tolerance.

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Key Words

Formylation, Triethylsilane

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ID: J54-Y2014