Palladium-Catalyzed Formylation of Aryl Halides with tert-Butyl Isocyanide
Xiao Jiang, Jin-Mei Wang, Ying Zhang, Zhong Chen, Yong-Ming Zhu* and Shun-Jun Ji*
*State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. Chinan, Email: zhuyongmingsuda.edu.cn, shunjunsuda.edu.cn
X. Jiang, J.-M. Wang, Y. Zhang, Z. Chen, Y.-M. Zhu, S.-J. Ji, Org. Lett., 2014, 16, 3492-3495.
DOI: 10.1021/ol5014262 (free Supporting Information)
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A palladium-catalyzed formylation of aryl halides with isocyanide in the presence of Et3SiH provides important aldehydes in good yield. This reaction offers mild conditions, convenient operation, low toxicity, and wide functional group tolerance.
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