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Decarboxylative Thioamidation of Arylacetic and Cinnamic Acids: A New Approach to Thioamides

Tirumaleswararao Guntreddi, Rajeshwer Vanjari and Krishna Nand Singh*

*Department of Chemistry (Centre of Advanced Study), Faculty of Science, Banaras Hindu University, Varanasi 221005, India, Email:

T. Guntreddi, R. Vanjari, K. N. Singh, Org. Lett., 2014, 16, 3624-3625.

DOI: 10.1021/ol501482g (free Supporting Information)

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A decarboxylative strategy for the synthesis of thioamides involves a three-component reaction of arylacetic or cinnamic acids, amines and elemental sulfur powder, without the need of a transition metal and an external oxidant.

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Key Words

thionation, amination, multicomponent reactions

ID: J54-Y2014