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A Protocol To Generate Phthaloyl Peroxide in Flow for the Hydroxylation of Arenes

Anders M. Eliasen, Randal P. Thedford, Karin R. Claussen, Changxia Yuan and Dionicio Siegel*

*Department of Chemistry, The University of Texas at Austin, 1 University Station, Austin, Texas 78712, United States, Email: dsiegelcm.utexas.edu

A. M. Eliasen, R. P. Thedford, K. R. Claussen, C. Yuan, D. Siegel, Org. Lett., 2014, 16, 3628-3631.

DOI: 10.1021/ol501497y (free Supporting Information)


Abstract

A flow protocol for the generation of phthaloyl peroxide in high purity (>95%) can be used to bypass the need to isolate and recrystallize phthaloyl peroxide, improving upon earlier batch procedures. The flow protocol for the formation of phthaloyl peroxide can be combined with arene hydroxylation reactions.


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Key Words

hydroxylation, phthaloyl peroxide


ID: J54-Y2014