A Convenient Practical Synthesis of Alkyl and Aryl Oxime Esters
S. Chandrappa Santosh Kumar, Nanjundaswamy Vijendra Kumar, Pullabhatla Srinivas, Bheemanakere Kempaiah Bettadaiah*
*Plantation Products, Spices and Flavour Technology
Department, CSIR-Central Food Technological Research Institute, Mysore 570020,
India, Email: bettadaiah
cftri.res.in
S. C. S. Kumar, N. V. Kumar, P. Srinivas, M. K. Bettadaiah, Synthesis, 2014, 46, 1847-1852.
DOI: 10.1055/s-0034-1378350
Abstract
A facile esterification of ketoximes and aldoximes in high yields can be performed using N-[3-(methylamino)propyl]-N′-ethylcarbodiimide hydrochloride (EDCI) in the presence of 4-(dimethylamino)pyridine (DMAP) as a catalyst at room temperature. The isolation and purification is very simple and for solid products, column chromatography is avoided.
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Key Words
oxime esters, aldoximes, ketoximes, EDCI, esterification, dehydration
ID: J66-Y2014
