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A Convenient Practical Synthesis of Alkyl and Aryl Oxime Esters

S. Chandrappa Santosh Kumar, Nanjundaswamy Vijendra Kumar, Pullabhatla Srinivas, Bheemanakere Kempaiah Bettadaiah*

*Plantation Products, Spices and Flavour Technology Department, CSIR-Central Food Technological Research Institute, Mysore 570020, India, Email:

S. C. S. Kumar, N. V. Kumar, P. Srinivas, M. K. Bettadaiah, Synthesis, 2014, 46, 1847-1852.

DOI: 10.1055/s-0034-1378350 (free Supporting Information)


A facile esterification of ketoximes and aldoximes in high yields can be performed using N-[3-(methylamino)propyl]-N′-ethylcarbodiimide hydrochloride (EDCI) in the presence of 4-(dimethylamino)pyridine (DMAP) as a catalyst at room temperature. The isolation and purification is very simple and for solid products, column chromatography is avoided.

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Key Words

oxime esters, aldoximes, ketoximes, EDCI, esterification, dehydration

ID: J66-Y2014