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Copper-Catalyzed Synthesis of Mixed Alkyl Aryl Phosphonates

Martín Fañanás-Mastral* and Ben L. Feringa*

*Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands, Email: m.fananas.mastralrug.nl, b.l.feringarug.nl

M. Fañanás-Mastral, B. L. Feringa, J. Am. Chem. Soc., 2014, 136, 9894-9897.

DOI: 10.1021/ja505281v (free Supporting Information)



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Abstract

Copper catalysis allows the direct oxygen-arylation of dialkyl phosphonates with diaryliodonium salts. This reaction proceeds with a wide range of phosphonates and phosphoramidates under mild conditions and gives mixed alkyl aryl phosphonates in very good yields and very good selectivity.

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Key Words

hydroxylation, phosphonates


ID: J48-Y2014