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An Improved Method for Difluorocyclopropanation of Alkenes

Duncan M. Gill, Neil McLay, Michael J. Waring, Christopher T. Wilkinson, Joseph B. Sweeney*

*Department of Chemical Sciences, University of Huddersfield, Queensgate, Huddersfield, West Yorkshire, HD1 3DH, UK, Email:

D. M. Gill, N. McLay, M. J. Waring, C. T. Wilkinson, J. B. Sweeney, Synlett, 2014, 25, 1756-1758.

DOI: 10.1055/s-0033-1341155


A MW-based protocol enables a rapid preparation of 1,1-difluorocyclopropanes, using fluorinated acetate salts. The new procedure is not only considerably faster than conventional methods, but it also employs easily removed, low boiling-point solvents and avoids the use of highly toxic or ozone-depleting substances.

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Key Words

cyclopropanation, perfluoroalkanes, difluoroalkanes, microwave synthesis, pharmacophore

ID: J60-Y2014