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Rational Design of a Second Generation Catalyst for Preparation of Allylsilanes Using the Silyl-Heck Reaction

Jesse R. McAtee, Glenn P. A. Yap and Donald A. Watson*

*Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, United States, Email:

J. R. McAtee, G. P. A. Yap, D. A. Watson, J. Am. Chem. Soc., 2014, 136, 10166-10172.

DOI: 10.1021/ja505446y


A second-generation ligand, bis(3,5-di-tert-butylphenyl)(tert-butyl)phosphine, enables the preparation of allylsilanes using the palladium-catalyzed silyl-Heck reaction. This ligand provides nearly complete suppression of starting material alkene isomerization.

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ID: J48-Y2014