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Palladium-Catalyzed Alkenylation of Ketone Enolates under Mild Conditions

Michael Grigalunas, Tobias Ankner, Per-Ola Norrby, Olaf Wiest and Paul Helquist*

*Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States, Email: phelquisnd.edu

M. Grigalunas, T. Ankner, P.-O. Norrby, O. Wiest, P. Helquist, Org. Lett., 2014, 16, 3970-3973.

DOI: 10.1021/ol5017965  (free Supporting Information)


Abstract

In a protocol for a mild, catalytic, intermolecular alkenylation of ketone enolates, Pd/Q-Phos as catalyst enables an efficient intermolecular coupling of various ketones with alkenyl bromides with a slight excess of LiHMDS at 0C.

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Ni-Catalyzed Alkenylation of Ketone Enolates under Mild Conditions: Catalyst Identification and Optimization

M. Grigalunas, T. Ankner, P.-O. Norrby, O. Wiest, P. Helquist, J. Am. Chem. Soc., 2015, 137, 7019-7022.


Key Words

alkenylation


ID: J54-Y2014