Palladium-Catalyzed Alkenylation of Ketone Enolates under Mild Conditions
Michael Grigalunas, Tobias Ankner, Per-Ola Norrby, Olaf Wiest and Paul Helquist*
*Department of Chemistry and Biochemistry, University of
Notre Dame, Notre Dame, Indiana 46556, United States, Email: phelquis
nd.edu
M. Grigalunas, T. Ankner, P.-O. Norrby, O. Wiest, P. Helquist, Org. Lett., 2014, 16, 3970-3973.
DOI: 10.1021/ol5017965
Abstract
In a protocol for a mild, catalytic, intermolecular alkenylation of ketone enolates, Pd/Q-Phos as catalyst enables an efficient intermolecular coupling of various ketones with alkenyl bromides with a slight excess of LiHMDS at 0°C.
see article for more examples
M. Grigalunas, T. Ankner, P.-O. Norrby, O. Wiest, P. Helquist, J. Am. Chem. Soc., 2015, 137, 7019-7022.
Key Words
ID: J54-Y2014
