Metal-Free Trifluoromethylation of Aromatic and Heteroaromatic Aldehydes and Ketones
Yupu Qiao, Tuda Si, Ming-Hsiu Yang and Ryan A. Altman*
*Department of Medicinal Chemistry, The University of Kansas, Lawrence, Kansas 66045, United States, Email: raaltmanku.edu
Y. Qiao, T. Si, M.-H. Yang, R. A. Altman, J. Org. Chem., 2014, 79, 7122-7131.
DOI: 10.1021/jo501289v (free Supporting Information)
see article fore more reactions
A one-pot metal-free decarboxylative procedure for accessing β,β,β-trifluoroethylarenes and -heteroarenes from readily available ketones and aldehydes features several benefits, including ease of operation, readily available reagents, mild reaction conditions, high functional-group compatibility, and scalability.
see article for more examples
B. R. Ambler, L. Zhu, R. A. Altman, J. Org. Chem., 2015, 80, 8449-8457.