Organic Chemistry Portal



Ni-Catalyzed Carboxylation of Unactivated Primary Alkyl Bromides and Sulfonates with CO2

Yu Liu, Josep Cornella and Ruben Martin*

*Institute of Chemical Research of Catalonia (ICIQ), Av. Pa´sos Catalans 16, 43007 Tarragona, Spain, Email:

Y. Liu, J. Cornella, R. Martin, J. Am. Chem. Soc., 2014, 136, 11212-11215.

DOI: 10.1021/ja5064586

see article for more reactions


A user-friendly and operationally simple Ni-catalyzed carboxylation of unactivated primary alkyl bromides and sulfonates with CO2 at atmospheric pressure is characterized by its mild conditions and remarkably wide scope without the need for air- or moisture-sensitive reagents.

see article for more examples

Ni-Catalyzed Carboxylation of Unactivated Alkyl Chlorides with CO2

M. B÷rjesson, T. Moragas, R. Martin, J. Am. Chem. Soc., 2016, 138, 7504-7507.

Ni-Catalyzed Direct Carboxylation of Benzyl Halides with CO2

T. Leˇn, A. Correa, R. Martin, J. Am. Chem. Soc., 2013, 135, 1221-1224.

Key Words

carboxylation, manganese

ID: J48-Y2014