Molybdenum-Mediated Desulfurization of Thiols and Disulfides

Zhen Wang, Yoichiro Kuninobu*, Motomu Kanai*

*Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan, Email: kuninobumol.f.u-tokyo.ac.jp, kanaimol.f.u-tokyo.ac.jp

Z. Wang, Y. Kuninobu, M. Kanai, Synlett, 2014, 25, 1869-1872.

DOI: 10.1055/s-0034-1378315

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Abstract

With a molybdenum hexacarbonyl mediated desulfurization of thiols and disulfides, sulfhydryl groups of aryl, benzyl, primary and secondary alkyl thiols, and S-S single bonds of disulfides can be removed. This reaction tolerates many functional groups and is not affected by steric hindrance.

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Key Words

desulfurization, molybdenum, thiols, disulfides, cleavage

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ID: J60-Y2014