Molybdenum-Mediated Desulfurization of Thiols and Disulfides
Zhen Wang, Yoichiro Kuninobu*, Motomu Kanai*
*Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan, Email: kuninobumol.f.u-tokyo.ac.jp, kanaimol.f.u-tokyo.ac.jp
Z. Wang, Y. Kuninobu, M. Kanai, Synlett, 2014, 25, 1869-1872.
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With a molybdenum hexacarbonyl mediated desulfurization of thiols and disulfides, sulfhydryl groups of aryl, benzyl, primary and secondary alkyl thiols, and S-S single bonds of disulfides can be removed. This reaction tolerates many functional groups and is not affected by steric hindrance.
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desulfurization, molybdenum, thiols, disulfides, cleavage