Organic Chemistry Portal

Abstracts

Search:

Ruthenium-Catalyzed N-Alkylation of Amines with Alcohols under Mild Conditions Using the Borrowing Hydrogen Methodology

Arrey B. Enyong* and Bahram Moasser

*Department of Chemistry, Georgetown Universiry, 37th Street & O Street NW, Washington, D.C. 20057, United States, India, Email: abe4georgetown.edu

A. B. Enyong, B. Moasser, J. Org. Chem., 2014, 79, 7559-7563.

DOI: 10.1021/jo501273t (free Supporting Information)


see article for more reactions

Abstract

A simple amino amide ligand enables a ruthenium-catalyzed one-pot alkylation of primary and secondary amines with simple alcohols. Using the alcohol as solvent, alkylation was achieved under mild conditions with high conversion and selectivity. Reactions can also be carried out at high temperatures in organic solvent with high selectivity using stoichiometric amounts of the alcohol.

see article for more examples



Key Words

amines


ID: J42-Y2014