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Ruthenium-Catalyzed N-Alkylation of Amines with Alcohols under Mild Conditions Using the Borrowing Hydrogen Methodology

Arrey B. Enyong* and Bahram Moasser

*Department of Chemistry, Georgetown Universiry, 37th Street & O Street NW, Washington, D.C. 20057, United States, India, Email:

A. B. Enyong, B. Moasser, J. Org. Chem., 2014, 79, 7559-7563.

DOI: 10.1021/jo501273t

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A simple amino amide ligand enables a ruthenium-catalyzed one-pot alkylation of primary and secondary amines with simple alcohols. Using the alcohol as solvent, alkylation was achieved under mild conditions with high conversion and selectivity. Reactions can also be carried out at high temperatures in organic solvent with high selectivity using stoichiometric amounts of the alcohol.

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Key Words


ID: J42-Y2014